Title: Which Treatment for Nonalcoholic Fatty Liver Disease?
VOLUME: 8 ISSUE: 8
Author(s):S. Moscatiello, R. Marzocchi, N. Villanova, E. Bugianesi and G. Marchesini
Affiliation:Unit of Clinical Dietetics,“Alma Mater Studiorum” University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, I-40138 Bologna, Italy.
Keywords:Orlistat, weight loss, Metformin, statins, Lipid peroxidation, diabetes
Abstract: Subjects with nonalcoholic fatty liver disease are at risk of progressive liver failure. Lifestyle changes including weight-loss strategies and increased physical activity remain the first-line approach, but a few pharmacological treatments have also been successfully tested. Several drugs improve biochemistry, only a few improve histology; in all cases, the results were not sustained after treatment stop. Pharmacological treatment is not so far indicated outside controlled clinical trials with histological outcomes.
