Inhibitors of c-jun-N-Terminal Kinase (JNK)

Author(s): Philip LoGrasso, Theodore Kamenecka

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 8 , 2008

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Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural classes including, aminopyrimidines and indazoles.

Keywords: c-jun-N-Terminal Kinase (JNK), mitogen activated protein (MAP), benzothiazole pyrimidines, benzothien-2-yl amides, indazoles, aminopyrimidines, aminopyridines, quinolines

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Article Details

Year: 2008
Page: [755 - 766]
Pages: 12
DOI: 10.2174/138955708784912120
Price: $65

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PDF: 10