Abstract
Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural classes including, aminopyrimidines and indazoles.
Keywords: c-jun-N-Terminal Kinase (JNK), mitogen activated protein (MAP), benzothiazole pyrimidines, benzothien-2-yl amides, indazoles, aminopyrimidines, aminopyridines, quinolines
Mini-Reviews in Medicinal Chemistry
Title: Inhibitors of c-jun-N-Terminal Kinase (JNK)
Volume: 8 Issue: 8
Author(s): Philip LoGrasso and Theodore Kamenecka
Affiliation:
Keywords: c-jun-N-Terminal Kinase (JNK), mitogen activated protein (MAP), benzothiazole pyrimidines, benzothien-2-yl amides, indazoles, aminopyrimidines, aminopyridines, quinolines
Abstract: Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural classes including, aminopyrimidines and indazoles.
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Cite this article as:
LoGrasso Philip and Kamenecka Theodore, Inhibitors of c-jun-N-Terminal Kinase (JNK), Mini-Reviews in Medicinal Chemistry 2008; 8 (8) . https://dx.doi.org/10.2174/138955708784912120
DOI https://dx.doi.org/10.2174/138955708784912120 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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