Endothelial Lipase: A Key Player in HDL Metabolism Modulates Inflammation and Atherosclerotic Risk

Author(s): Pascual DeSantis, Trey Coleman, Stephan Schiekofer, Peter P. Nawroth, Paul Schlimmer, Jochen G. Schneider

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 6 , 2008

Become EABM
Become Reviewer
Call for Editor


Endothelial Lipase (EL) is a newly identified member of the triacylglycerol lipase family. Recent studies suggested that EL may be an important determinant of HDL-metabolism and inflammation acting at the level of the vessel wall. The aim of this review is to summarize important facts derived from experimental approaches and from epidemiologic human studies to provide a comprehensive view on the role of EL in inflammation and atherogenesis as well as target for potential pharmaceutical interventions.

Keywords: HDL metabolism, atherosclerosis, inflammation

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Published on: 01 March, 2012
Page: [619 - 627]
Pages: 9
DOI: 10.2174/138955708784534427
Price: $65

Article Metrics

PDF: 5