Title: Statins-Mediated Inhibition of Rho GTPases as a Potential Tool in Anti-Tumor Therapy
VOLUME: 8 ISSUE: 6
Author(s):Chiara Riganti, Elisabetta Aldieri, Sophie Doublier, Amalia Bosia and Dario Ghigo
Affiliation:Dipartimento di Genetica, Biologia e Biochimica, Via Santena 5/bis, 10126 Torino, Italy.
Keywords:Rho GTPases, cancer, isoprenylation, statins, chemotherapy
Abstract: Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.
