Selective Estrogen Receptor Modulator Medicinal Chemistry At Merck. A Review

Author(s): T. A. Blizzard

Journal Name: Current Topics in Medicinal Chemistry

Volume 8 , Issue 9 , 2008

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Selective Estrogen Receptor Modulators (SERMs) have been the subject of extensive medicinal chemistry efforts at several pharmaceutical companies, including Merck. The Merck effort produced a wide variety of SERMs including ER-?? selective antagonists and ER-?? agonists in addition to balanced (non-selective) analogs. This article will provide a broad overview of the Merck SERM medicinal chemistry effort as published in the literature through early 2008.

Keywords: hormone replacement therapy, Spiroindenes, Dihydrobenzoxathiins, Benzochromenones, Androstenes

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Article Details

Year: 2008
Page: [792 - 812]
Pages: 21
DOI: 10.2174/156802608784535066
Price: $65

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