Abstract
Selective Estrogen Receptor Modulators (SERMs) have been the subject of extensive medicinal chemistry efforts at several pharmaceutical companies, including Merck. The Merck effort produced a wide variety of SERMs including ER-?? selective antagonists and ER-?? agonists in addition to balanced (non-selective) analogs. This article will provide a broad overview of the Merck SERM medicinal chemistry effort as published in the literature through early 2008.
Keywords: hormone replacement therapy, Spiroindenes, Dihydrobenzoxathiins, Benzochromenones, Androstenes
Current Topics in Medicinal Chemistry
Title: Selective Estrogen Receptor Modulator Medicinal Chemistry At Merck. A Review
Volume: 8 Issue: 9
Author(s): T. A. Blizzard
Affiliation:
Keywords: hormone replacement therapy, Spiroindenes, Dihydrobenzoxathiins, Benzochromenones, Androstenes
Abstract: Selective Estrogen Receptor Modulators (SERMs) have been the subject of extensive medicinal chemistry efforts at several pharmaceutical companies, including Merck. The Merck effort produced a wide variety of SERMs including ER-?? selective antagonists and ER-?? agonists in addition to balanced (non-selective) analogs. This article will provide a broad overview of the Merck SERM medicinal chemistry effort as published in the literature through early 2008.
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Cite this article as:
Blizzard A. T., Selective Estrogen Receptor Modulator Medicinal Chemistry At Merck. A Review, Current Topics in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/156802608784535066
DOI https://dx.doi.org/10.2174/156802608784535066 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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