Title: Synthesis of 5-Arylidene Barbiturates: A Novel Class of DPPH Radical Scavengers
VOLUME: 5 ISSUE: 4
Author(s):Khalid M. Khan, Muhammad Ali, Asma Ajaz, Shahnaz Perveen, M. Iqbal Choudhary and Atta-ur-Rahman
Affiliation:H. E. J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
Keywords:Barbiturates, DPPH, Antioxidant, Cytotoxic, Diseases
Abstract: Arylidene barbiturates 2-19 have been synthesized and their antioxidant and cytotoxic potentials have been evaluated. These compounds showed a moderate to excellent antioxidant activity in relevant antioxidant assay with no toxicity. A structure-activity relationship has been discussed. All the compounds were fully characterized by spectroscopic techniques.
