Synthesis of 5-Arylidene Barbiturates: A Novel Class of DPPH Radical Scavengers

Author(s): Khalid M. Khan, Muhammad Ali, Asma Ajaz, Shahnaz Perveen, M. Iqbal Choudhary, Atta-ur-Rahman

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 4 , 2008

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Arylidene barbiturates 2-19 have been synthesized and their antioxidant and cytotoxic potentials have been evaluated. These compounds showed a moderate to excellent antioxidant activity in relevant antioxidant assay with no toxicity. A structure-activity relationship has been discussed. All the compounds were fully characterized by spectroscopic techniques.

Keywords: Barbiturates, DPPH, Antioxidant, Cytotoxic, Diseases

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Article Details

Year: 2008
Page: [286 - 291]
Pages: 6
DOI: 10.2174/157018008784619889
Price: $65

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