Towards a Causal Model for Disgust in the Anxiety Disorders: An Integration of Evidence from Neuroscience

Author(s): Josh M. Cisler, Bunmi O. Olatunji

Journal Name: Current Psychiatry Reviews
Continued as Current Psychiatry Research and Reviews

Volume 4 , Issue 2 , 2008


Abstract:

Research implicates the emotion of disgust in particular anxiety disorders, but possible processes by which disgust can cause anxiety have not been articulated. We review data from studies of the functional neuroanatomy of disgust in order to elucidate possible processes by which disgust can cause anxiety disorders. First, we examine whether fear and disgust involve different neural substrates. Despite inconsistencies, the data suggest that the amygdala is critical for fear and the anterior insula is critical for disgust. Second, we examine whether the anterior insula fits into current neurobiological models of fear and anxiety. Recent research suggests that the insula projects to neural circuits underlying fear and anxiety and is also involved in activation of the hypothalamic-pituitary-adrenal axis stress response. Additionally, the insula may mediate interoceptive awareness, a critical component underlying anxiety. These functions of the insula provide possible routes by which disgust interacts with and sensitizes the fear and anxiety circuits in order to produce pathological anxiety. The derived temporal routes of disgusts role in anxiety foster testable predictions that may help future research determine if and how disgust functions in anxiety.

Keywords: Disgust, anxiety, contamination fears, blood-injection-injury, anterior insula

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2008
Page: [101 - 107]
Pages: 7
DOI: 10.2174/157340008784529304
Price: $58

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