Thermal N-9 → N-7 Isomerization of (6-Substituted)-9-(2,3-Dihydro-5H-1,4-Benzodioxepin-3-yl)-9H-Purines in Solution: Mechanistic Aspects

Author(s): M. A. Gallo, A. Espinosa, J. M. Campos.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 5 , Issue 2 , 2008

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Abstract:

The purine ring system is undoubtedly among the most ubiquitous of all the heterocyclic compounds. In recent years modified purine structures both of natural and synthetic origin have been a rich source of biologically active materials. The halogen at 6 position of the purine moiety of the (RS)-9 or 7-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-9H-or 7Hpurines shows an interesting reactivity which is presented and discussed. The anticarcinogenic potential of the target molecules is reported against the MCF-7 cancer cell line.

Keywords: Amination, antitumour compounds, benzodioxepins, purines, suzuki reaction, trifluoromethylation reaction

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2008
Page: [128 - 133]
Pages: 6
DOI: 10.2174/157019308784223569
Price: $65

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