Title: E-Cadherin Upregulation as a Therapeutic Goal in Cancer Treatment
VOLUME: 8 ISSUE: 5
Author(s):E. W. Howard, K. D. Camm, Y. C. Wong and X. H. Wang
Affiliation:Department of Anatomy,Laboratory Block, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, SAR, China.
Keywords:E-cadherin, cell adhesion, epithelial-mesenchymal transition, epigenetics, transcriptional repressors, chemotherapy, metastasis, cancer
Abstract: We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.
