E-Cadherin Upregulation as a Therapeutic Goal in Cancer Treatment

Author(s): E. W. Howard, K. D. Camm, Y. C. Wong, X. H. Wang

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 5 , 2008

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We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.

Keywords: E-cadherin, cell adhesion, epithelial-mesenchymal transition, epigenetics, transcriptional repressors, chemotherapy, metastasis, cancer

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Article Details

Year: 2008
Page: [496 - 518]
Pages: 23
DOI: 10.2174/138955708784223521
Price: $65

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