Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

4-Hydroxyphenylglycine-Based Polymer-Bound Amino Alcohols and insitu- Generated Oxazaborolidines for Enantioselective Reductions

Author(s): Manfred Braun, Michael Sigloch and Jens Cremer

Volume 5, Issue 4, 2008

Page: [244 - 248] Pages: 5

DOI: 10.2174/157017808784049551

Price: $65

Abstract

The chiral amino alcohol HOC6H4CH(NH2)C(C6H5)2OH (4) that is derived from (R)-4-hydroxyphenylglycine has been converted into novel soluble and insoluble polymer-bound reagents 5. After in-situ conversion into oxazaborolidines, they serve for enantioselective reductions of acetophenone to deliver (S)-1-phenylethanol (6) in up to 83% enantiomeric excess.

Keywords: Asymmetric synthesis, polystyrene, boron, ketone, catalysis

Next »

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy