Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury

Author(s): P. C. Burcham, L. M. Kaminskas, D. Tan, S. M. Pyke

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 4 , 2008

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Abstract:

This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to “carbonyl stress” during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.

Keywords: Carbonyl stress, acrolein, protein adducts, hydralazine

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2008
Page: [319 - 330]
Pages: 12
DOI: 10.2174/138955708783955953
Price: $65

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