Synthesis and Antitubercular Evaluation of N-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide Derivatives

Author(s): Marcelle de L. Ferreira, Laura N. de F. Cardoso, Raoni S.B. Goncalves, Emerson T. da Silva, Maria Cristina S. Lourenco, Felipe R. Vicente, Marcus V.N. de Souza

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 2 , 2008

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The present article describes a series of eighteen N-[(E)-(hydroxy, methoxy and ethoxy substitutedphenyl) methylidene]isonicotinohydrazide derivatives, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μg/ml. Compounds 2a, 2d-f, and 2h exhibited a significant activity (0.31-1.25 μg/ml) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good start point to find new lead compounds in the fight against multi-drug resistant tuberculosis.

Keywords: Tuberculosis, Multidrug-resistance, Isoniazid, Isonicotinohydrazides, Antimycobacterial activity, Alamar Blue assay

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Article Details

Year: 2008
Published on: 01 March, 2012
Page: [137 - 140]
Pages: 4
DOI: 10.2174/157018008783928472
Price: $65

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