Phenylpyazoleanilides as a Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 1: A New Class of Orally Available Immunomodulators

Author(s): Hiroyuki Ushio, Seigo Ishibuchi, Kunitomo Adachi, Kouichi Oshita, Kenji Chiba

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 2 , 2008

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In research for a new immunomodulator, we discoverd a novel hydroxypiperidine derivative 9h which was a potent inhibitor of IL-15induced T cell activation. Further modification of 9h gave a potent and orally active agent 10 which was effective in a mouse CIA model.

Keywords: Phenylpyrazoleanilide, IL-15, Prodrug, CIA

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Article Details

Year: 2008
Page: [111 - 115]
Pages: 5
DOI: 10.2174/157018008783928427

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