Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors

Mei, Xiao; Bi-Ke, Zhu; Yu,Lin Jiang

Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors

Author(s): Mei Xiao, Bi-Ke Zhu, Yu Lin Jiang

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Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 2 , 2008

DOI : 10.2174/157018008783928445

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Abstract:

Four known small molecule uracil-DNA glycosylase (UNG) inhibitors were synthesized and tested against human melanoma cells, IgR3 and MM200. They were found to be effective against cell proliferation at micromolar concentrations and to operate through a nonapoptotic mechanism. Thus, small molecules that target UNG may be useful as potential chemotherapeutic agents against human melanoma.

Keywords: Uracil-DNA glycosylase, Small molecule inhibitors, Chemo-preventive agents, Melanoma, IgR3, MM200, Anticancer drugs

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Letters in Drug Design & Discovery

Title: Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors

VOLUME: 5 ISSUE: 2

Author(s):Mei Xiao, Bi-Ke Zhu and Yu Lin Jiang

Affiliation:Department of Chemistry,College of Arts and Sciences, East Tennessee State University, Johnson City, TN 37614, USA.

Keywords:Uracil-DNA glycosylase, Small molecule inhibitors, Chemo-preventive agents, Melanoma, IgR3, MM200, Anticancer drugs

Abstract: Four known small molecule uracil-DNA glycosylase (UNG) inhibitors were synthesized and tested against human melanoma cells, IgR3 and MM200. They were found to be effective against cell proliferation at micromolar concentrations and to operate through a nonapoptotic mechanism. Thus, small molecules that target UNG may be useful as potential chemotherapeutic agents against human melanoma.

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Mei Xiao, Bi-Ke Zhu and Yu Lin Jiang, “ Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors”, Letters in Drug Design & Discovery (2008) 5: 108. https://doi.org/10.2174/157018008783928445

DOI https://doi.org/10.2174/157018008783928445	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2008

Page: [108 - 110]
Pages: 3
DOI: 10.2174/157018008783928445
Price: $65

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