Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors

Author(s): Mei Xiao, Bi-Ke Zhu, Yu Lin Jiang

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 2 , 2008

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Four known small molecule uracil-DNA glycosylase (UNG) inhibitors were synthesized and tested against human melanoma cells, IgR3 and MM200. They were found to be effective against cell proliferation at micromolar concentrations and to operate through a nonapoptotic mechanism. Thus, small molecules that target UNG may be useful as potential chemotherapeutic agents against human melanoma.

Keywords: Uracil-DNA glycosylase, Small molecule inhibitors, Chemo-preventive agents, Melanoma, IgR3, MM200, Anticancer drugs

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Article Details

Year: 2008
Page: [108 - 110]
Pages: 3
DOI: 10.2174/157018008783928445
Price: $65

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