Inhibitory Feature of the Proprotein Convertases Prosegments

Author(s): Abdel-Majid Khatib, Yannick Bontemps, Marion Lapierre, Geraldine Siegfried, Fabien Calvo

Journal Name: Medicinal Chemistry

Volume 4 , Issue 2 , 2008


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Abstract:

The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.

Keywords: Proprotein convertases, prosegments, inhibitors, processing, maturation, substrates

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2008
Published on: 01 March, 2012
Page: [116 - 120]
Pages: 5
DOI: 10.2174/157340608783789176
Price: $65

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