Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Glycolipid Stimulators for NKT Cells Bearing Invariant Vα19-Jα33 TCR α Chains

Author(s): M. Shimamura

Volume 8, Issue 3, 2008

Page: [285 - 289] Pages: 5

DOI: 10.2174/138955708783744119

Price: $65

Abstract

Attempts have been made to find specific antigens for a novel NKT cell subset bearing invariant Vα19-Jα33 TCR α chains (Vα19 NKT cell). Comprehensive examinations revealed substantial antigenic activity in synthetic α- mannosylceramide (ManCer) that was presented by MR1. Structural modification of the sphingosine moiety of α-ManCer improved antigenic activity to enhance either Th1 or Th2 – promoting cytokine production by Vα19 NKT cells. Such α- ManCer analogues will be useful for developing new therapies as immunomodulators.

Keywords: Glycolipid, FTY720, NKT cell, invariant TCR, immunomodulator, non-classical MHC class I


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy