Title: HPLC as a Tool in Medicinal Chemistry for the Monitoring of Tricyclic Antidepressants in Biofluids
VOLUME: 8 ISSUE: 3
Author(s):V. F. Samanidou, M. K. Nika and I. N. Papadoyannis
Affiliation:Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki,Thessaloniki, 541 24 Greece.
Keywords:HPLC, tricyclic antidepressants, monitoring, medicinal chemistry, biological fluids
Abstract: HPLC is discussed as an essential tool in medicinal chemistry for the monitoring of tricyclic antidepressants in biofluids, providing clinicians with efficient fast and reliable methods to define individual optimum therapeutic concentrations in treatment of depressions. Additional information on mechanism of action, structure activity relationship and metabolism is provided.
