Inhibition of Orotidine 5-Monophosphate Decarboxylase and Its Therapeutic Potential

Author(s): L. P. Kotra, M. E. Meza-Avina, L. Wei, M. G. Buhendwa, E. Poduch, A. M. Bello, E. F. Pai

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 3 , 2008

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Orotidine 5-monophosphate decarboxylase (ODCase) is among the most proficient enzymes, and catalyzes the decarboxylation of OMP to UMP. An overview of ODCase and various proposals for its catalytic mechanism of decarboxylation are briefly presented here. A number of inhibitors of ODCase and new developments in the X-ray structures of ODCases from different species are discussed in the context of their therapeutic potential against cancer and infectious diseases. Latest discoveries in the inhibition of ODCase, for example using the novel C6 substitutions on the uridine, open new doors for drug discovery targeting parasitic diseases such as malaria.

Keywords: Orotidine 5'-monophosphate decarboxylase, de novo nucleotide synthesis, pyrimidine nucleotides, drug design

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Article Details

Year: 2008
Page: [239 - 247]
Pages: 9
DOI: 10.2174/138955708783744065
Price: $65

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PDF: 10