A Docking Modelling Rationally Predicts Strong Binding of Bisphenol A to Estrogen-Related Receptor γ

Author(s): Takeru Nose, Yasuyuki Shimohigashi

Journal Name: Protein & Peptide Letters

Volume 15 , Issue 3 , 2008

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Abstract:

A computer-aided docking study was carried out to quickly clarify the binding structure of the ligand-receptor complex between bisphenol A (BPA), a well-known endocrine disruptor, and estrogen-related receptor γ (ERRγ). The resulting complex indicated that BPA binds to the ligand-binding pocket of ERRγ without any disruptions of the activation conformation.

Keywords: Estrogen-related receptor γ, bisphenol A, endocrine disruptors, docking calculation

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2008
Page: [290 - 296]
Pages: 7
DOI: 10.2174/092986608783744261
Price: $65

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