Title: Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines
VOLUME: 5 ISSUE: 2
Author(s):Laurent Brard, Rakesh K. Singh, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Russell Hopson and Nicholi Vorsa
Affiliation:Assistant Professor of Obstetrics and Gynecology, The Warren Alpert Medical School of Brown University, Director, Molecular Therapeutics Laboratory, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Women and Infants Hospital of RI, 101 Dudley Street, Providence, RI 02905, USA.
Keywords:Thiazolines, eschenmoser, cytotoxicity, neuroblastoma, ovarian cancer
Abstract: The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.
