A Novel and Expeditious Approach to Symmetrical and Unsymmetrical 5,5-Spiroimide Building Blocks

Author(s): Aadm Daich, Iyad Allous, Sebastien Comesse

Journal Name: Letters in Organic Chemistry

Volume 5 , Issue 2 , 2008

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Symmetrical and unsymmetrical spiro-bis-imides and corresponding 3-methoxycarbonyl succinimides were prepared in very good yields starting from dimethyl malonate and suitable α-bromoacetamides in a one-pot procedure or two-steps sequence, respectively. The mechanistic aspects of these transformations were also discussed.

Keywords: Diazaspiro[4.4]nonane, peptide coupling, spirocyclisation, carbanion, cascade, tandem

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Article Details

Year: 2008
Page: [73 - 78]
Pages: 6
DOI: 10.2174/157017808783743902
Price: $65

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