Enzymes in Protein Ligation: The Coupling of Peptides, Peptide Nucleic Acids and Proteins by Sortase A

Author(s): S. Pritz

Journal Name: Mini-Reviews in Organic Chemistry

Volume 5 , Issue 1 , 2008

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Abstract:

The chemical synthesis of proteins, as well as the modification of expressed proteins, requires highly selective reactions. Ligation methods offer feasible tools for this purpose. This mini-review focuses on enzymatic methods for protein ligation; in particular, on the use of the transpeptidase sortase.

Keywords: Enzymatic ligation, sortase, proteins, peptides, peptide nucleic acids

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2008
Page: [47 - 52]
Pages: 6
DOI: 10.2174/157019308783498188

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