Use of Liposomal Drugs in the Treatment of Rheumatoid Arthritis

Author(s): Dimple Chopra, Monica Gulati, Saranjit Singh, Sanjiv Duggal, Rajiv Kumar

Journal Name: Current Rheumatology Reviews

Volume 4 , Issue 1 , 2008

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Rheumatoid arthritis is an autoimmune disease that results in joint deformity and disability. Conventional nonsteroidal anti-inflammatory drugs (NSAIDs), steroids and disease modifying antirheumatic drugs (DMARDs) are used for its treatment. Unconventional therapies, like enzyme oligodeoxy nucleotides, boron neutron capture therapy & radioisotopes are also being tried. The use of all these drugs is limited by a number of adverse effects. These side effects have been overcome to a large extent by the use of liposomes as delivery systems. This review presents rationale for the use of liposomes for the treatment of arthritis. Systemic as well as intra-articular delivery of liposome encapsulated anti-arthritic drugs is discussed. Success and limitations of this approach are also discussed by taking examples of different drug classes.

Keywords: Arthritis, liposomes, DMARDs, NSAIDs, corticosteroids, intra-articular

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Article Details

Year: 2008
Page: [63 - 70]
Pages: 8
DOI: 10.2174/157339708783497964

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