Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease

Author(s): Nahum Mendez-Sanchez, Hector Baptista-Gonzalez, Norberto C. Chavez-Tapia, Daniel Zamora-Valdes, Misael Uribe

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 2 , 2008


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Abstract:

Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.

Keywords: Iron, iron overload, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2008
Published on: 01 March, 2012
Page: [171 - 174]
Pages: 4
DOI: 10.2174/138955708783498087
Price: $65

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