N-Myristoyltransferase: A Novel Target

Author(s): M. P. Toraskar, K. K. Prasad, V. J. Kadam

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 2 , 2008

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Abstract:

Myristoyl-CoA:Protein N-myristoyltranferase (NMT) is a cytosolic monomeric enzyme which catalyses the transfer of a rare fatty acid , myristate from myristoyl-CoA to the N-terminal glycine residue of a variety of eukaryotic and viral proteins. N-myristoyltransferase is a novel target for Anticancer, Antiviral and antifungal agents. Recent Nmyristoyltransferase inhibitors like benzofurans and benzothiazole derivatives show in vivo antifungal activity and are promising selective fungal N-myristoyltransferase inhibitors.

Keywords: N-myristoyltransferase, myristoylation, benzofurans, benzothiazoles, antifungal, Candida albicans, anticancer, antiviral

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2008
Page: [142 - 149]
Pages: 8
DOI: 10.2174/138955708783498159
Price: $65

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