Abstract
A large number of human diseases are caused by fungus and the plant kingdom has proven to be a source of antifungal compounds. This work describes the in vitro activity of the natural product (R)-goniothalamin and its synthetic enantiomer, (S)-goniothalamin, against eleven strains of human pathogenic fungi. The minimum inhibitory concentration (MIC) values for both enantiomers were lower than 100 μg/mL for nine of the fungus strains studied. MIC values for both enantiomers against isolates of the dimorphic fungus Paracoccidioides braziliensis were in the range of 7-22 μg/mL. (R)- and (S)- goniothalamin were selective for the fungi strains presenting minimal toxic effects on mammalian kidney (Vero) and lung (V79) cell lines.
Keywords: Fungi infections, Goniothalamus, Goniothalamin, Antifungal agents, Minimum inhibitory concentration, Antiproliferative activity
Letters in Drug Design & Discovery
Title: Antifungal Activity of Goniothalamin Enantiomers
Volume: 5 Issue: 1
Author(s): Angelo de Fatima, Cleide Viviane Buzanello Martins, Maria Aparecida de Resende, Thais Furtado Ferreira Magalhaes, Bruno Henrique Santiago Lima, Gisele Almeida Watanabe, Ana Lucia Tasca Gois Ruiz, Joao Ernesto de Carvalho and Ronaldo Aloise Pilli
Affiliation:
Keywords: Fungi infections, Goniothalamus, Goniothalamin, Antifungal agents, Minimum inhibitory concentration, Antiproliferative activity
Abstract: A large number of human diseases are caused by fungus and the plant kingdom has proven to be a source of antifungal compounds. This work describes the in vitro activity of the natural product (R)-goniothalamin and its synthetic enantiomer, (S)-goniothalamin, against eleven strains of human pathogenic fungi. The minimum inhibitory concentration (MIC) values for both enantiomers were lower than 100 μg/mL for nine of the fungus strains studied. MIC values for both enantiomers against isolates of the dimorphic fungus Paracoccidioides braziliensis were in the range of 7-22 μg/mL. (R)- and (S)- goniothalamin were selective for the fungi strains presenting minimal toxic effects on mammalian kidney (Vero) and lung (V79) cell lines.
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Fatima de Angelo, Martins Buzanello Cleide Viviane, de Resende Aparecida Maria, Ferreira Magalhaes Furtado Thais, Santiago Lima Henrique Bruno, Watanabe Almeida Gisele, Gois Ruiz Lucia Tasca Ana, de Carvalho Ernesto Joao and Pilli Aloise Ronaldo, Antifungal Activity of Goniothalamin Enantiomers, Letters in Drug Design & Discovery 2008; 5 (1) . https://dx.doi.org/10.2174/157018008783406732
DOI https://dx.doi.org/10.2174/157018008783406732 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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