Flavylium Salts as Precursors of Biologically Active Chalcones

Author(s): Karl A. Werbovetz, Tesmol G. George, Julian Richard, Todd Barszcz, Jeffrey Capers

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 1 , 2008

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Abstract:

Several flavylium salts showed potent (albeit nonselective) activity against L. donovani axenic amastigotes and T. b. brucei bloodstream forms in vitro (IC50 values ranging from 0.75 to 35 μM). The trans-chalcone, which forms from the corresponding flavylium salt at neutral pH in aqueous solution, is proposed to be the active species.

Keywords: Leishmania, Trypanosome, Chalcone, Flavylium salt

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2008
Page: [69 - 73]
Pages: 5
DOI: 10.2174/157018008783406697

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