Central Administration of L-Ser-L-His and L-Ile-L-His Induced Sedative Effects Under an Acute Stressful Condition in Chicks

Author(s): Mitsuhiro Furuse, Yousuke Tsuneyoshi, Shozo Tomonaga, Haruka Yamane, Koji Morishita, D. Michael Denbow

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 1 , 2008

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Carnosine (β-alanyl-L-histidine) is rich in the skeletal muscle and brain, but the function of dipeptides like carnosine in the brain has not been clarified. We previously showed that β-alanyl dipeptides with carboxyl terminal branched chain amino acids induced hyperactivity in chicks when intracerebroventricularly (i.c.v.) administrated. In the present study we investigated the effect of amino terminal histidine related dipeptides under isolation induced stress. I.c.v. injection of L-seryl-L-histidine and L-isoleucyl-L-histidine induced sedation with a weak hypnotic effect, and L-valyl-Lhistidine lowered spontaneous activity in chicks. However, L-alanyl-L-histidine, glycyl-L-histidine and L-methionyl-Lhistidine had no significant effects in all parameteres determined. These results indicate that L-seryl-L-histidine and Lisoleucyl- L-histidine dipeptides may be effective in improving anxiety and have novel functional effects in the brain.

Keywords: Carnosine, Histidine, Dipeptides, Intracerebroventricular injection, Brain, Chicks

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Article Details

Year: 2008
Page: [65 - 68]
Pages: 4
DOI: 10.2174/157018008783406679

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