Inhibition of 17β -Hydroxysteroid Dehydrogenase (17β -HSD) by Imidazole-Based Compounds

Author(s): Sabbir Ahmed, Moniola S. Olusanjo, Imran Shahid, Caroline P. Owen

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 1 , 2008

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Abstract:

We report the results of the biochemical evaluation of a series of imidazole-based compounds against the hydroxysteroid dehydrogenase (HSD) family of enzymes, in particular, types 1 and 3 of 17β-HSD and 3β-HSD. The results show that the synthesised compounds were good inhibitors of this family of enzymes.

Keywords: Enzyme, Inhibition, Azole, Hydroxysteroid dehydrogenase, 17α-hydroxylase, 17,20-lyase

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2008
Page: [48 - 51]
Pages: 4
DOI: 10.2174/157018008783406705

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