Design and Synthesis of 2-Azetidinone Cholesterol Absorption Inhibitors

Author(s): Huibin Zhang, Yubin Wang, Rui Zhao, Wenlong Huang, Yunman Li, Jinpei Zhou

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 1 , 2008

Become EABM
Become Reviewer


In this paper we reported the design, synthesis of a series 2-azetidinones with ester or amide group in C-3 sidechain. Their cholesterol absorption inhibition activity was assessed in orally dosed, cholesterol-fed hamsters. It was demonstrated that compound 20c∼d with amid group in C-3 sidechain exhibited high cholesterol absorption inhibition activity.

Keywords: 2-Azetidinones, C-3 sidechain, Cholesterol absorption inhibition activity

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Page: [39 - 42]
Pages: 4
DOI: 10.2174/157018008783406741

Article Metrics

PDF: 26