Evaluation of the Ability of an Organic Derivative of Ruthenium(II) to Reinforce the Cytotoxicity of Fast Neutron Against Malignant Cells in Culture

P., Bischoff; L., Leyva; F., Malek; S., Benzina; J.,M. Denis; J., Gueulette; P., Dufour; C., Gaiddon; J.,P. Loeffler; C., Sirlin; M., Pfeffer

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Evaluation of the Ability of an Organic Derivative of Ruthenium(II) to Reinforce the Cytotoxicity of Fast Neutron Against Malignant Cells in Culture

Author(s): P. Bischoff, L. Leyva, F. Malek, S. Benzina, J. M. Denis, J. Gueulette, P. Dufour, C. Gaiddon, J. P. Loeffler, C. Sirlin, M. Pfeffer

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Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 1 , 2008

DOI : 10.2174/157018008783406714

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The effect of combining RDC-11 (a new ruthenium organometallic complex) and fast neutrons (high-LET radiations) has been evaluated in RDM4 and U-87 tumor cell lines. After co-treatment, a substantial reduction of cell growth was recorded, which appears not to be correlated with the induction of apoptosis.

Keywords: Ruthenium-based anticancer drugs, Apoptosis, High-LET radiation, Concomitant chemoradiotherapy, Fast neutrons

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Letters in Drug Design & Discovery

Title: Evaluation of the Ability of an Organic Derivative of Ruthenium(II) to Reinforce the Cytotoxicity of Fast Neutron Against Malignant Cells in Culture

VOLUME: 5 ISSUE: 1

Author(s):P. Bischoff, L. Leyva, F. Malek, S. Benzina, J. M. Denis, J. Gueulette, P. Dufour, C. Gaiddon, J. P. Loeffler, C. Sirlin and M. Pfeffer

Affiliation:Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD), 1 place de l'Hopital, 67091 Strasbourg-France.

Keywords:Ruthenium-based anticancer drugs, Apoptosis, High-LET radiation, Concomitant chemoradiotherapy, Fast neutrons

Abstract: The effect of combining RDC-11 (a new ruthenium organometallic complex) and fast neutrons (high-LET radiations) has been evaluated in RDM4 and U-87 tumor cell lines. After co-treatment, a substantial reduction of cell growth was recorded, which appears not to be correlated with the induction of apoptosis.

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P. Bischoff, L. Leyva, F. Malek, S. Benzina, J. M. Denis, J. Gueulette, P. Dufour, C. Gaiddon, J. P. Loeffler, C. Sirlin and M. Pfeffer, “ Evaluation of the Ability of an Organic Derivative of Ruthenium(II) to Reinforce the Cytotoxicity of Fast Neutron Against Malignant Cells in Culture”, Letters in Drug Design & Discovery (2008) 5: 1. https://doi.org/10.2174/157018008783406714

DOI https://doi.org/10.2174/157018008783406714	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X

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VOLUME: 5
ISSUE: 1
Year: 2008

Page: [1 - 6]
Pages: 6
DOI: 10.2174/157018008783406714

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