Evaluation of the Ability of an Organic Derivative of Ruthenium(II) to Reinforce the Cytotoxicity of Fast Neutron Against Malignant Cells in Culture

Author(s): P. Bischoff, L. Leyva, F. Malek, S. Benzina, J. M. Denis, J. Gueulette, P. Dufour, C. Gaiddon, J. P. Loeffler, C. Sirlin, M. Pfeffer

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 1 , 2008

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Abstract:

The effect of combining RDC-11 (a new ruthenium organometallic complex) and fast neutrons (high-LET radiations) has been evaluated in RDM4 and U-87 tumor cell lines. After co-treatment, a substantial reduction of cell growth was recorded, which appears not to be correlated with the induction of apoptosis.

Keywords: Ruthenium-based anticancer drugs, Apoptosis, High-LET radiation, Concomitant chemoradiotherapy, Fast neutrons

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Article Details

VOLUME: 5
ISSUE: 1
Year: 2008
Page: [1 - 6]
Pages: 6
DOI: 10.2174/157018008783406714

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