Carbohydrate-Based Drugs in the Treatment of Epilepsy, Depression and Other Affective Disorders

Author(s): Cecilia H. Marzabadi, Ian Jamie Talisman

Journal Name: Current Topics in Medicinal Chemistry

Volume 8 , Issue 2 , 2008

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Mental illness affects a quarter of the US population. Recently, it has been shown that new, carbohydrate-based drugs hold promise in the treatment of central nervous system (CNS) disorders. A variety of ways in which drugs of this sort may reduce the symptoms of epilepsy, depression and other affective disorders have been proposed, including: targeting the immune system, disrupting glycolysis, acting at different sites in the hypothalamic-pituitary-adrenal (HPA) axis, and targeting specific biochemical pathways such as the inositol pathway. In the present review, the structureactivity relationships (SARs) of a wide variety of CNS-active carbohydrates are presented.

Keywords: Glycolysis, topiramate, saponins, steroidal glycosides, capsular saccharides

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Article Details

Year: 2008
Published on: 01 March, 2012
Page: [159 - 170]
Pages: 12
DOI: 10.2174/156802608783378846
Price: $65

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