Abstract
The combination of electrochemistry coupled on-line to mass spectrometry (EC-MS) forms a powerful analytical technique with unique applications in the fields of drug metabolism and proteomics. In this review the latest developments are surveyed from both instrumental and application perspectives. The limitations and solutions for coupling an electrochemical system to a mass spectrometer are discussed. The electrochemical mimicking of drug metabolism, specifically by Cytochrome P450, is high-lighted as an application with high biomedical relevance. The EC-MS analysis of proteins also has promising new applications for both proteomics research and biomarker discovery. EC-MS has furthermore advantages for improved analyte detection with mass spectrometry, both for small molecules and large biomolecules. Finally, potential future directions of development of the technique are briefly discussed.
Keywords: Electrochemistry, mass spectrometry, drug metabolism, protein oxidation
Mini-Reviews in Medicinal Chemistry
Title: Electrochemistry-Mass Spectrometry in Drug Metabolism and Protein Research
Volume: 8 Issue: 1
Author(s): Hjalmar P. Permentier, Andries P. Bruins and Rainer Bischoff
Affiliation:
Keywords: Electrochemistry, mass spectrometry, drug metabolism, protein oxidation
Abstract: The combination of electrochemistry coupled on-line to mass spectrometry (EC-MS) forms a powerful analytical technique with unique applications in the fields of drug metabolism and proteomics. In this review the latest developments are surveyed from both instrumental and application perspectives. The limitations and solutions for coupling an electrochemical system to a mass spectrometer are discussed. The electrochemical mimicking of drug metabolism, specifically by Cytochrome P450, is high-lighted as an application with high biomedical relevance. The EC-MS analysis of proteins also has promising new applications for both proteomics research and biomarker discovery. EC-MS has furthermore advantages for improved analyte detection with mass spectrometry, both for small molecules and large biomolecules. Finally, potential future directions of development of the technique are briefly discussed.
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Cite this article as:
Permentier P. Hjalmar, Bruins P. Andries and Bischoff Rainer, Electrochemistry-Mass Spectrometry in Drug Metabolism and Protein Research, Mini-Reviews in Medicinal Chemistry 2008; 8 (1) . https://dx.doi.org/10.2174/138955708783331586
DOI https://dx.doi.org/10.2174/138955708783331586 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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