Advanced Glycation and ROS: A Link between Diabetes and Heart Failure

Author(s): Armando Rojas, Enrique Mercadal, Hector Figueroa, Miguel A. Morales

Journal Name: Current Vascular Pharmacology

Volume 6 , Issue 1 , 2008

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Despite many advances achieved to date, heart failure (HF) remains a leading cause of morbidity and mortality. There is a widely-accepted consensus that HF and diabetes are strongly linked by at least 3 mechanisms: associated comorbidities, coronary atherosclerosis or a specific diabetic cardiomiopathy. For the last 2 mechanisms, advanced glycation end-products may contribute to trigger key processes relevant to HF by affecting cardiac function through cross-linking or receptor engagement. This review focuses on the main effects of advanced glycation end-products on cardiomyocytes and endothelial cell function. Some pharmacological approaches are also discussed.

Keywords: Advanced glycation, heart failure, glucose imbalance, diabetes, cardiomyocytes, oxidative stress

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Article Details

Year: 2008
Page: [44 - 51]
Pages: 8
DOI: 10.2174/157016108783331312
Price: $65

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PDF: 26