Combretastatin A-4 Analogs as Anticancer Agents

Author(s): Anurag Chaudhary, S. N. Pandeya, P. Kumar, P. P. Sharma, S. Gupta, N. Soni, K. K. Verma, G. Bhardwaj

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 12 , 2007

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Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.

Keywords: Combretastatin A-4, antitubulin, antivascular, cytotoxicity, structure-activity relationship

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Article Details

Year: 2007
Page: [1186 - 1205]
Pages: 20
DOI: 10.2174/138955707782795647
Price: $65

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