Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents

Title: Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents

Volume: 4 Issue: 8

Author(s): Ahmed Kamal, S. Kaleem Ahmed, K. Srinivasa Reddy, M. Naseer A. Khan, Rajesh V.C.R.N.C. Shetty, B. Siddhardha, U. S.N. Murty, Arnab China and V. Nagaraja

Affiliation:

Keywords: Benzothiadiazines, Benzothiazoles, Antibacterial activity, DNA gyrase inhibition

Abstract: A new series of benzothiazolo-benzothiadiazine hybrids (9a-g) has been synthesized and evaluated for their antibacterial activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in this series exhibited antibacterial activity comparable to ampicillin. In addition, some of the compounds showed DNA gyrase inhibitory activity at a moderate level compared to ciprofloxacin.

Cite this article as:

Kamal Ahmed, Ahmed Kaleem S., Reddy Srinivasa K., A. Khan Naseer M., Shetty V.C.R.N.C. Rajesh, Siddhardha B., Murty S.N. U., China Arnab and Nagaraja V., Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents, Letters in Drug Design & Discovery 2007; 4 (8) . https://dx.doi.org/10.2174/157018007782794563