Inhibition of Aromatase (AR) by Benzyl Azole-Based Compounds

Author(s): Shaheen Adat, Caroline P. Owen, Sabbir Ahmed

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 8 , 2007

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Abstract:

We report the results of the evaluation of a series of benzyl imidazole-based compounds against the enzyme aromatase (AR). The results show that the synthesised compounds were potent inhibitors of AR in comparison to the standard compound aminoglutethimide (AG).

Keywords: Enzyme, Inhibition, Azole, Estrogen synthetase, Aromatase

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Article Details

VOLUME: 4
ISSUE: 8
Year: 2007
Page: [545 - 549]
Pages: 5
DOI: 10.2174/157018007782794554
Price: $65

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