Inhibition of Aromatase (AR) by Benzyl Azole-Based Compounds

Shaheen  Adat,  Caroline P. Owen and   Sabbir  Ahmed

Inhibition of Aromatase (AR) by Benzyl Azole-Based Compounds

Author(s): Shaheen Adat, Caroline P. Owen, Sabbir Ahmed

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Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 8 , 2007

DOI : 10.2174/157018007782794554

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We report the results of the evaluation of a series of benzyl imidazole-based compounds against the enzyme aromatase (AR). The results show that the synthesised compounds were potent inhibitors of AR in comparison to the standard compound aminoglutethimide (AG).

Keywords: Enzyme, Inhibition, Azole, Estrogen synthetase, Aromatase

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Letters in Drug Design & Discovery

Title: Inhibition of Aromatase (AR) by Benzyl Azole-Based Compounds

VOLUME: 4 ISSUE: 8

Author(s):Shaheen Adat, Caroline P. Owen and Sabbir Ahmed

Affiliation:Department of Pharmacy,School of Pharmacy and Chemistry, Kingston University, Penrhyn Road,Kingston upon Thames, Surrey, KT1 2EE, UK.

Keywords:Enzyme, Inhibition, Azole, Estrogen synthetase, Aromatase

Abstract: We report the results of the evaluation of a series of benzyl imidazole-based compounds against the enzyme aromatase (AR). The results show that the synthesised compounds were potent inhibitors of AR in comparison to the standard compound aminoglutethimide (AG).

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Shaheen Adat, Caroline P. Owen and Sabbir Ahmed, “ Inhibition of Aromatase (AR) by Benzyl Azole-Based Compounds”, Letters in Drug Design & Discovery (2007) 4: 545. https://doi.org/10.2174/157018007782794554

DOI https://doi.org/10.2174/157018007782794554	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X

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Article Details

VOLUME: 4
ISSUE: 8
Year: 2007

Page: [545 - 549]
Pages: 5
DOI: 10.2174/157018007782794554
Price: $65

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