Abstract
Although the use of stem cells in cell-replacement therapies by transplantation is obvious, another equally important and interesting application of stem cells is to use them in disease modeling. Disease models serve as a platform to dissect the biochemical mechanisms of normal phenotypes and the processes which go awry during disease conditions. Particularly in complex, multigenic diseases, molecular studies lead to a greater understanding of the disease, and perhaps more targeted approaches for therapies. Stem cells provide an ideal in vitro system in which to study events related to development at the molecular and cellular level. Neural stem cells have been used as excellent models to study the mechanisms of differentiation of cells of the central nervous system. These studies may be particularly relevant to diseases of complex etiology such as psychiatric illnesses, neurodegenerative diseases and brain tumors. Stem cell-derived systems are also being developed to create models of cardiovascular disease. The application of stem cells to the study of cardiovascular illnesses, and vertebrate heart development, is discussed.
Keywords: Stem cells, embryonic, neural, cardiac, autism, glioma
Current Stem Cell Research & Therapy
Title: Stem Cells as In Vitro Models of Disease
Volume: 2 Issue: 4
Author(s): Pilar Ruiz-Lozano and Prithi Rajan
Affiliation:
Keywords: Stem cells, embryonic, neural, cardiac, autism, glioma
Abstract: Although the use of stem cells in cell-replacement therapies by transplantation is obvious, another equally important and interesting application of stem cells is to use them in disease modeling. Disease models serve as a platform to dissect the biochemical mechanisms of normal phenotypes and the processes which go awry during disease conditions. Particularly in complex, multigenic diseases, molecular studies lead to a greater understanding of the disease, and perhaps more targeted approaches for therapies. Stem cells provide an ideal in vitro system in which to study events related to development at the molecular and cellular level. Neural stem cells have been used as excellent models to study the mechanisms of differentiation of cells of the central nervous system. These studies may be particularly relevant to diseases of complex etiology such as psychiatric illnesses, neurodegenerative diseases and brain tumors. Stem cell-derived systems are also being developed to create models of cardiovascular disease. The application of stem cells to the study of cardiovascular illnesses, and vertebrate heart development, is discussed.
Export Options
About this article
Cite this article as:
Ruiz-Lozano Pilar and Rajan Prithi, Stem Cells as In Vitro Models of Disease, Current Stem Cell Research & Therapy 2007; 2 (4) . https://dx.doi.org/10.2174/157488807782793772
DOI https://dx.doi.org/10.2174/157488807782793772 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Neurodevelopmental Delay and Intellectual Disability in Pediatric Heart Transplant
Current Psychiatry Reviews Phosphoregulation of Twist1 Provides a Mechanism of Cell Fate Control
Current Medicinal Chemistry 30 Years Lost in Anesthesia Theory
Cardiovascular & Hematological Agents in Medicinal Chemistry New Insights in Congenital Diaphragmatic Hernia
Current Respiratory Medicine Reviews Psychosocial Implications During Adolescence for Infant Heart Transplant Recipients
Current Cardiology Reviews Mechanical Ventilation Following Cardiac Surgery in Children
Current Respiratory Medicine Reviews Perinatal Heart Programming: Long-term Consequences
Current Medicinal Chemistry Interaction of the Heart and Lungs During Exercise: Physiology and Pathophysiology in Children with Congenital Heart Disease
Current Respiratory Medicine Reviews Congenital Malformations Attributed to Prenatal Exposure to Cyclophosphamide
Anti-Cancer Agents in Medicinal Chemistry Neonatology in the United States: Where we are, and where we are Going
Current Pediatric Reviews Does Data Shape Moral Decision? Or Do Values Shape the Data?
Current Pediatric Reviews Sedation and Analgesia in Pediatric Intensive Care
Current Drug Targets Clinical and Pharmacological Aspects of Immunoprophylaxis for Respiratory Syncytial Virus Infection in High-Risk Infants
Current Drug Metabolism Immunologic Considerations in Heart Transplantation for Congenital Heart Disease
Current Cardiology Reviews Paroxetine Use During Pregnancy and Perinatal Outcomes Including Types of Cardiac Malformations in Quebec and France: A Short Communication
Current Drug Safety Genetics of Cardiomyopathies: Novel Perspectives with Next Generation Sequencing
Current Pharmaceutical Design Pathophysiology of Post-Operative Low Cardiac Output Syndrome
Current Vascular Pharmacology Role of Genetic Factors in the Pathogenesis of Radial Deficiencies in Humans
Current Genomics General Anesthetics in Pediatric Anesthesia: Influences on the Developing Brain
Current Drug Targets Predictors of Ominous Outcome in Infants who Undergo Cardiac Surgery and Cardiopulmonary By-Pass: S100B Protein
CNS & Neurological Disorders - Drug Targets