Sleep deprivation and sleep disruption have long been associated with mood disorders, both as a cause as well as an effect. Sleep-disordered breathing results in significant and persistent sleep disruption, which in turn leads to significant neurocognitive deficits [1,2] and major depression [3-6]. Various pathophysiologic mechanisms may play a role in modulating mood changes in these patients. Treatment for sleep-disordered breathing often improves mood [4, 7], though the data may suggest a placebo response . Patients with sleep-disordered breathing should be carefully screened for mood disorders, and patients with major depression should be screened for possible underlying sleep-disordered breathing.
Keywords: Depression in OSA, sleep and depression, OSA and mood disorder, OSA and sleep disruption
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