Recent Developments and Trends in 18F-Radiochemistry: Syntheses and Applications

Author(s): Ralf Schirrmacher, Carmen Wangler, Esther Schirrmacher

Journal Name: Mini-Reviews in Organic Chemistry

Volume 4 , Issue 4 , 2007

Become EABM
Become Reviewer
Call for Editor


In this short review we describe recent methods and novel trends for the introduction of fluorine-18 into molecules which in turn are intended to serve as imaging agents for the in vivo imaging modality positron emission tomography (PET). These 18F-labeling schemes are based on enzymatic fluorination, the use of ionic liquids, protic solvents acting as catalysts, application of “click chemistry”, thiol-reactive labeling agents for peptide and protein labeling and the most recent introduction of “non-classical” radiochemistry based on organo-phosphorous, organo-boron and organo-silicon radiochemistry. The latter approach for the first time introduced an 18F-chemistry characterized by high selectivity and unique efficiency making complicated work-up procedures obsolete.

Keywords: Fluorine-18, positron emission tomography (PET), labeling chemistry

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2007
Published on: 01 March, 2012
Page: [317 - 329]
Pages: 13
DOI: 10.2174/157019307782411699

Article Metrics

PDF: 79