Pseudopeptide Synthesis via Fmoc Solid-Phase Synthetic Methodology

Author(s): Predrag Cudic, Maciej Stawikowski

Journal Name: Mini-Reviews in Organic Chemistry

Volume 4 , Issue 4 , 2007

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Peptidomimetic modifications are frequently used as attractive methods to provide more conformationally constrained and thus more stable and bioactive peptides. Among peptidomimetic approaches, particularly attractive are pseudopeptides, or peptide bond surrogates in which peptide bonds have been replaced with other chemical groups. Since these peptidomimetics can be constructed in a modular way from orthogonally protected monomeric building blocks, solid-phase Fmoc methodology, used routinely for peptide synthesis, emerged as a particularly attractive synthetic approach.

Keywords: Peptidomimetics, pseudopeptides, isosteres, Fmoc solid-phase synthesis

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Article Details

Year: 2007
Page: [268 - 280]
Pages: 13
DOI: 10.2174/157019307782411716
Price: $65

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