Abstract
Using bioinformatics techniques and sequence analyses algorithms, we identified that tumor necrosis factor-α (TNF-α) and nitric oxide (NO) have a significant role in the pathobiology of insulin resistance syndrome, a condition that is common in subjects with abdominal obesity, hypertension, dyslipidemia, atherosclerosis, and coronary heart disease and are accompanied by endothelial dysfunction due to reduced endothelial nitric oxide generation. TNF-α has neurotoxic actions, stimulates inducible NO synthase activity, and modulates the expression of neurotransmitters involved in the control of feeding and thermogenesis. NO is a neurotransmitter and influences secretion and actions of various hypothalamic peptides and neuropeptides. Insulin suppresses the production of TNF-α but stimulates that of endothelial NO. This close interaction between TNF-α, NO, hypothalamic peptides, and insulin suggests that regulation of TNF-α and NO production and action could be critical in the management of insulin resistance syndrome and its associated conditions.
Keywords: Insulin resistance, tumor necrosis factor, nitric oxide, hypothalamus, neurotransmission, insulin, endothelium, inflammation
Current Nutrition & Food Science
Title: Bioinformatics Analysis of Functional Protein Sequences Reveals a Role for Tumor Necrosis Factor-α and Nitric Oxide in Insulin Resistance Syndrome
Volume: 3 Issue: 4
Author(s): Appa Rao Allam, Hanuman Thota, Srihari Ramisetti, Kodanda R.K.R. Tirumala, Sridhar R. Gumpeny, Annapurna Akula, Suresh Babu Changalasetty, Siva Reddy Challa, Veera Swamy Thota, V. V. Satyanarayana Kopparthi and Undurt N. Das
Affiliation:
Keywords: Insulin resistance, tumor necrosis factor, nitric oxide, hypothalamus, neurotransmission, insulin, endothelium, inflammation
Abstract: Using bioinformatics techniques and sequence analyses algorithms, we identified that tumor necrosis factor-α (TNF-α) and nitric oxide (NO) have a significant role in the pathobiology of insulin resistance syndrome, a condition that is common in subjects with abdominal obesity, hypertension, dyslipidemia, atherosclerosis, and coronary heart disease and are accompanied by endothelial dysfunction due to reduced endothelial nitric oxide generation. TNF-α has neurotoxic actions, stimulates inducible NO synthase activity, and modulates the expression of neurotransmitters involved in the control of feeding and thermogenesis. NO is a neurotransmitter and influences secretion and actions of various hypothalamic peptides and neuropeptides. Insulin suppresses the production of TNF-α but stimulates that of endothelial NO. This close interaction between TNF-α, NO, hypothalamic peptides, and insulin suggests that regulation of TNF-α and NO production and action could be critical in the management of insulin resistance syndrome and its associated conditions.
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Cite this article as:
Allam Rao Appa, Thota Hanuman, Ramisetti Srihari, Tirumala R.K.R. Kodanda, Gumpeny R. Sridhar, Akula Annapurna, Changalasetty Babu Suresh, Challa Reddy Siva, Thota Swamy Veera, Satyanarayana Kopparthi V. V. and Das N. Undurt, Bioinformatics Analysis of Functional Protein Sequences Reveals a Role for Tumor Necrosis Factor-α and Nitric Oxide in Insulin Resistance Syndrome, Current Nutrition & Food Science 2007; 3 (4) . https://dx.doi.org/10.2174/1573401310703040250
DOI https://dx.doi.org/10.2174/1573401310703040250 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
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