Abstract
In antibody directed enzyme prodrug therapy (ADEPT) an antibody bound enzyme is targeted to tumor cells. This allows for selective activation of a nontoxic prodrug to a cytotoxic agent at the tumor site for cancer therapy. Site-selective prodrug activation results in reduced side effects in remote tissue. This article reviews ADEPT with emphasis on the chemical viewpoint and recent developments.
Keywords: Antibody Directed Enzyme Prodrug Therapy, ADEPT, Anticancer Therapy, Alkaline Phosphatase, Amino Peptidases, Aryl Sulfatase, Carboxylesterase, Carboxypeptidase A, Carboxypeptidase G2 (CpG2), Cytosine Deaminase
Mini-Reviews in Medicinal Chemistry
Title: Antibody Directed Enzyme Prodrug Therapy (ADEPT) and Related Approaches for Anticancer Therapy
Volume: 1 Issue: 4
Author(s): M. Jung
Affiliation:
Keywords: Antibody Directed Enzyme Prodrug Therapy, ADEPT, Anticancer Therapy, Alkaline Phosphatase, Amino Peptidases, Aryl Sulfatase, Carboxylesterase, Carboxypeptidase A, Carboxypeptidase G2 (CpG2), Cytosine Deaminase
Abstract: In antibody directed enzyme prodrug therapy (ADEPT) an antibody bound enzyme is targeted to tumor cells. This allows for selective activation of a nontoxic prodrug to a cytotoxic agent at the tumor site for cancer therapy. Site-selective prodrug activation results in reduced side effects in remote tissue. This article reviews ADEPT with emphasis on the chemical viewpoint and recent developments.
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Cite this article as:
Jung M., Antibody Directed Enzyme Prodrug Therapy (ADEPT) and Related Approaches for Anticancer Therapy, Mini-Reviews in Medicinal Chemistry 2001; 1 (4) . https://dx.doi.org/10.2174/1389557013406747
DOI https://dx.doi.org/10.2174/1389557013406747 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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