Non Peptidic Ligands at the Opioid Receptor Like-1 (ORL-1)

Author(s): D. Barlocco, L. Toma, G. Cignarella

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 1 , Issue 4 , 2001


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Abstract:

Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other diseases. This review deals with non-peptidic ligands at the ORL-1 receptor, focusing on their structural and binding properties. Agonism or antagonism evidenced from functional experiments is also commented. For some compounds, possible therapeutic applications are considered.

Keywords: Opioid Receptor Like-1 (ORL-1), Nociceptin (orphanin FQ), Dynorphin A

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Article Details

VOLUME: 1
ISSUE: 4
Year: 2001
Page: [363 - 375]
Pages: 13
DOI: 10.2174/1389557013406657
Price: $65

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