Regional Anesthesia and Analgesia: Their Role in Postoperative Outcome

Author(s): G. Ekatodramis

Journal Name: Current Topics in Medicinal Chemistry

Volume 1 , Issue 3 , 2001

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Increasing insight into the mechanisms of perioperative physiologic responses and the resultant effects on patient outcome suggests that some responses may be detrimental to long-term recovery. Thus, initial belief in the adaptive wisdom of the body [1] has been supplanted by the concept that a stress-free perioperative period may minimize detrimental physiologic responses and resultant morbidity [2]. The perioperative use of neuraxial- or regional anesthesia and analgesia have profound inhibitory effects on the bodys response to surgery compared to the same operation performed during general anesthesia alone. Increasing evidence has emerged suggesting that such afferent nociceptive blockade may improve a variety of postoperative morbidity parameters and improve surgical outcome. We review the clinical evidence from studies examining the effects of regional anesthesia and analgesia on postoperative morbidity in specific physiologic systems.


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Article Details

Year: 2001
Published on: 01 March, 2012
Page: [182 - 192]
Pages: 11
DOI: 10.2174/1568026013395236
Price: $65

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