Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimers Disease

Author(s): Ana Castro, Ana Martinez

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 1 , Issue 3 , 2001

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Recently advances in understanding the molecular basis of Alzheimers disease have led to the consideration of the relationship between cholinergic inhibitors and amyloid deposition as a new hypothesis for the future rational design of effective anti-Alzheimer drugs. In the present review, the non-cholinergic functions of acetylcholinesterase (AChE) and the therapeutic potential of peripheral and dual binding site AChE inhibitors in delaying the neurodegenerative process will be discussed.

Keywords: Acetylcholinesterase Inhibitors, Alzheimers Disease, Anti-Alzheimer drugs

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Article Details

Year: 2001
Page: [267 - 272]
Pages: 6
DOI: 10.2174/1389557013406864
Price: $65

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