Medicinal Chemistry of Nicotinamide in the Treatment of Ischemia and Reperfusion

Author(s): J. Yang, L. K. Klaidman, J. D. Adams

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 2 , Issue 2 , 2002

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Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.

Keywords: nicotinamide, poly(adp-ribose) polymerase inhibitors, poly(adp-ribose)glycohydrolase inhibitors, glycohydrolase

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Article Details

Year: 2002
Page: [125 - 134]
Pages: 10
DOI: 10.2174/1389557024605483
Price: $65

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